Impaired Control of Effector T cells by Regulatory T Cells: a Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease? Running title: Defective responses to regulatory T cells in celiac disease
نویسندگان
چکیده
Nadia Belhadj Hmida , Mélika Ben Ahmed, Amel Moussa , Majd Ben Rejeb, Yosra Said, Nadia Kourda, Bertrand Meresse, Maha Abdeladhim, Hechmi Louzir, Nadine Cerf-Bensussan 1 Department of Clinical Immunology, Institut Pasteur de Tunis, Tunisia 2 Tunis El Manar University, Tunisia 3 Department of Gastroenterology and Hepatology, Hôpital Charles Nicolle, Tunis, Tunisia 4 Department of Pathology, Hôpital Charles Nicolle, Tunis, Tunisia 5 INSERM, U989, France 6 Université Paris Descartes, France * These two authors contributed equally to the work
منابع مشابه
Suppressive Mechanisms Induced by Tregs in Celiac Disease
Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4+ T cells wit...
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